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Helps Reduce Inflammation, Particularly in Combination With Glucosamine and Chondroitin
Due to its role as part of the powerful antioxidant superoxide dismutase (SOD), manganese may reduce inflammation.

Manganese is important in the formation and functioning of the superoxide dismutase (SOD) antioxidant, which can help reduce damage to your cells.

Research suggests that SOD is potentially useful as a therapeutic agent for inflammatory disorders (13Trusted Source).
Evidence supports that combining manganese with glucosamine and chondroitin can reduce osteoarthritis pain.
Osteoarthritis is considered a wear-and-tear disease leading to the loss of cartilage and joint pain. Synovitis, which is inflammation of the membrane inside the joints, is a critical driver of osteoarthritis (14Trusted Source).
In one study in 93 people with osteoarthritis, 52% reported symptom improvements after 4 and 6 months of taking a manganese, glucosamine and chondroitin supplement (15Trusted Source).
However, it seems that only those with minor osteoarthritis benefit from the supplement. Those with a severe condition did not report the same improvement (15Trusted Source).
Another 16-week study in men with chronic pain and degenerative joint disease found that taking the supplement helped decrease inflammation specifically in the knees (16Trusted Source).

It appears that manganese may contribute to decreasing inflammation and pain associated with inflammatory diseases. ufabet